Oncolytic viruses (OV) are replication-conditional viruses with relative tumor selectivity. Several have been published in peer-reviewed literature. These pages are meant to provide lists of such OVs as a quick reference guide. We will update these biannually by querying PubMed. We also accept corrections or additions of published (in peer-reviewed literature) OVs by scientists or other interested parties. These can be emailed to: EA.Chiocca@osumc.edu.

OV WEB Tables [single html table] - OV WEB Tables [single MS Word .doc]

• Table I -OVs targeting oncogenic ras or defective IFN pathways.
• Table II - OVs targeting defective p16 tumor suppressor pathways.
• Table III - OVs targeting defective p53 tumor suppressor pathway.
• Table IV - Targeting of OV with tumor-specific promoters
• Table V - Targeting with “tumor-selective” infection.
• Table VI - Other mechanisms of OV targeting.
• Table VII -OVs that express anti-cancer cDNAs.

References

• BRPtumor.org - BRPtumor Collaboration:

  In spite of advancements in diagnostics and therapeutics, the outcome for patients suffering from highly malignant brain tumors remains uniformly fatal. Responsible for this grim prognosis are the rapid tumor growth, clonal heterogeneity, acquired treatment resistance and the extensive tumor invasion, rendering cytoreductive therapy ineffective. We believe that malignant tumors behave as complex dynamic, adaptive and self-organizing biosystems rather than as unorganized cell masses. Employing a profoundly interdisciplinary approach, our multi-institutional Bioengineering Research Partnership Team investigates a set of groundbreaking tumor biology concepts. Paradigm-shifting insights into brain tumor growth, heterogeneity, invasion and angiogenesis are expected, which in turn may eventually build the basis for the development of more successful therapeutic strategies.